Details of the Target

General Information of Target

Target ID LDTP07904
Target Name Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
Gene Name TMUB2
Gene ID 79089
Synonyms
Transmembrane and ubiquitin-like domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MISRHLQNNLMSVDPASSQAMELSDVTLIEGVGNEVMVVAGVVVLILALVLAWLSTYVAD
SGSNQLLGAIVSAGDTSVLHLGHVDHLVAGQGNPEPTELPHPSEGNDEKAEEAGEGRGDS
TGEAGAGGGVEPSLEHLLDIQGLPKRQAGAGSSSPEAPLRSEDSTCLPPSPGLITVRLKF
LNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHC
HRSPPGSAVPGPSASLAPSATEPPSLGVNVGSLMVPVFVVLLGVVWYFRINYRQFFTAPA
TVSLVGVTVFFSFLVFGMYGR
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q71RG4
Ensemble ID
ENST00000319511.6
HGNC ID
HGNC:28459

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K179(4.89); K212(7.14)  LDD0277  [1]
DBIA
 Probe Info  		C166(1.46)  LDD3319  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A498 C166(1.12)  LDD2259  [2]
 LDCM0023  KB03 A498 C166(1.17)  LDD2676  [2]
 LDCM0024  KB05 MEWO C166(1.46)  LDD3319  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Gap junction beta-3 protein (GJB3) Connexin family O75712
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) MS4A family Q96JQ5
Uroplakin-1b (UPK1B) Tetraspanin (TM4SF) family O75841
Wolframin (WFS1) . O76024
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prosaposin receptor GPR37 (GPR37) G-protein coupled receptor 1 family O15354
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Progranulin (GRN) Granulin family P28799
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Gelsolin (GSN) Villin/gelsolin family P06396
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Thrombospondin type-1 domain-containing protein 7A (THSD7A) . Q9UPZ6
Transmembrane protein 52B (TMEM52B) . Q4KMG9
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019