Details of the Target

General Information of Target

Target ID LDTP07883
Target Name Ubiquitin carboxyl-terminal hydrolase 50 (USP50)
Gene Name USP50
Gene ID 373509
Synonyms
Ubiquitin carboxyl-terminal hydrolase 50; EC 3.4.19.12; Ubiquitin-specific peptidase 50
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSQPSLPADDFDIYHVLAECTDYYDTLPVKEADGNQPHFQGVTGLWNLGNTCCVNAISQ
CLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAYLMTDMWLGDSDCVSPEIFWSA
LGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSYEKGSTQRCCRKWITTETS
IITQLFEEQLNYSIVCLKCEKCTYKNEVFTVFSLPIPSKYECSLRDCLQCFFQQDALTWN
NEIHCSFCETKQETAVRASISKAPKIIIFHLKRFDIQGTTKRKLRTDIHYPLTNLDLTPY
ICSIFRKYPKYNLCAVVNHFGDLDGGHYTAFCKNSVTQA
Target Bioclass
Enzyme
Family
Peptidase C19 family
Function
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates the inflammasome signaling pathway by deubiquitinating 'Lys-63'-linked polyubiquitination of the PYCARD/ASC adapter protein. Regulates the ubiquitination and stability of the ACE2 protein. Acts as a negative regulator of the G2/M checkpoint pathway, by preventing serine/threonine kinase WEE1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint.
Uniprot ID
Q70EL3
Ensemble ID
ENST00000532404.6
HGNC ID
HGNC:20079

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		N.A.  LDD0447  [1]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.