Details of the Target
General Information of Target
| Target ID | LDTP07874 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ubiquitin carboxyl-terminal hydrolase 49 (USP49) | |||||
| Gene Name | USP49 | |||||
| Gene ID | 25862 | |||||
| Synonyms |
Ubiquitin carboxyl-terminal hydrolase 49; EC 3.4.19.12; Deubiquitinating enzyme 49; Ubiquitin thioesterase 49; Ubiquitin-specific-processing protease 49 |
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| 3D Structure | ||||||
| Sequence |
MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEE
TGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSM ASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALER KKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATL KLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGK TQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRE LHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGT TRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYH CIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQL MIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLDKETFAYDL SAVVMHHGKGFGSGHYTAYCYNTEGGFWVHCNDSKLNVCSVEEVCKTQAYILFYTQRTVQ GNARISETHLQAQVQSSNNDEGRPQTFS |
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| Target Bioclass |
Enzyme
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| Family |
Peptidase C19 family
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| Subcellular location |
Nucleus
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| Function |
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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C41(0.00); C46(0.00) | LDD0241 | [1] | |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Nicotinamide phosphoribosyltransferase (NAMPT) | NAPRTase family | P43490 | |||
| Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) | . | Q13451 | |||
Transcription factor
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Zinc finger protein 774 (ZNF774) | Krueppel C2H2-type zinc-finger protein family | Q6NX45 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Pentatricopeptide repeat-containing protein 2, mitochondrial (PTCD2) | PTCD2 family | Q8WV60 | |||