Details of the Target

General Information of Target

Target ID LDTP07857
Target Name Hemojuvelin (HJV)
Gene Name HJV
Gene ID 148738
Synonyms
HFE2; RGMC; Hemojuvelin; Hemochromatosis type 2 protein; Hemojuvelin BMP coreceptor; RGM domain family member C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEPGQSPSPRSSHGSPPTLSTLTLLLLLCGHAHSQCKILRCNAEYVSSTLSLRGGGSSG
ALRGGGGGGRGGGVGSGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCS
RQGPTAPPPPRGPALPGAGSGLPAPDPCDYEGRFSRLHGRPPGFLHCASFGDPHVRSFHH
HFHTCRVQGAWPLLDNDFLFVQATSSPMALGANATATRKLTIIFKNMQECIDQKVYQAEV
DNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKV
AEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHS
CVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFV
LWLCIQ
Target Bioclass
Other
Family
Repulsive guidance molecule (RGM) family
Subcellular location
Cell membrane
Function Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Uniprot ID
Q6ZVN8
Ensemble ID
ENST00000336751.11
HGNC ID
HGNC:4887

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.S155PfsTer91 .
ICC12 SNV: p.L414I .
IM95 Deletion: p.F170SfsTer76 .
LNCaP clone FGC SNV: p.R98H .
MCC26 SNV: p.S416F .
MOLT4 SNV: p.R176C .
SHP77 SNV: p.H166R .
SNU1 SNV: p.L294F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C95(1.29)  LDD3413  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 IPC-298 C95(1.40)  LDD2400  [1]
 LDCM0023  KB03 IPC-298 C95(1.40)  LDD2817  [1]
 LDCM0024  KB05 RVH-421 C95(1.29)  LDD3413  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840