Details of the Target

General Information of Target

Target ID LDTP07829
Target Name Teashirt homolog 1 (TSHZ1)
Gene Name TSHZ1
Gene ID 10194
Synonyms
SDCCAG33; TSH1; Teashirt homolog 1; Antigen NY-CO-33; Serologically defined colon cancer antigen 33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRRKQQAPRRSAAYVPEEELKAAEIDEEHVEDDGLSLDIQESEYMCNEETEIKEAQSYQ
NSPVSSATNQDAGYGSPFSESSDQLAHFKGSSSREEKEDPQCPDSVSYPQDSLAQIKAVY
ANLFSESCWSSLALDLKKSGSTTSTNDASQKESSAPTPTPPTCPVSTTGPTTSTPSTSCS
SSTSHSSTTSTSSSSGYDWHQAALAKTLQQTSSYGLLPEPSLFSTVQLYRQNNKLYGSVF
TGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNRDKDSEKTKRWSKPRKRSLMEMEGK
EDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVPAITKLVPSTKKRALQDLA
PPCSPEPAGMAAEVALSESAKDQKAANPYVTPNNRYGYQNGASYTWQFEARKAQILKCME
CGSSHDTLQQLTAHMMVTGHFLKVTTSASKKGKQLVLDPVVEEKIQSIPLPPTTHTRLPA
SSIKKQPDSPAGSTTSEEKKEPEKEKPPVAGDAEKIKEESEDSLEKFEPSTLYPYLREED
LDDSPKGGLDILKSLENTVSTAISKAQNGAPSWGGYPSIHAAYQLPGTVKPLPAAVQSVQ
VQPSYAGGVKSLSSAEHNALLHSPGSLTPPPHKSNVSAMEELVEKVTGKVNIKKEERPPE
KEKSSLAKAASPIAKENKDFPKTEEVSGKPQKKGPEAETGKAKKEGPLDVHTPNGTEPLK
AKVTNGCNNLGIIMDHSPEPSFINPLSALQSIMNTHLGKVSKPVSPSLDPLAMLYKISNS
MLDKPVYPATPVKQADAIDRYYYENSDQPIDLTKSKNKPLVSSVADSVASPLRESALMDI
SDMVKNLTGRLTPKSSTPSTVSEKSDADGSSFEEALDELSPVHKRKGRQSNWNPQHLLIL
QAQFASSLRETTEGKYIMSDLGPQERVHISKFTGLSMTTISHWLANVKYQLRRTGGTKFL
KNLDTGHPVFFCNDCASQFRTASTYISHLETHLGFSLKDLSKLPLNQIQEQQNVSKVLTN
KTLGPLGATEEDLGSTFQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLIYVTELEKQ
Target Bioclass
Transcription factor
Family
Teashirt C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
Uniprot ID
Q6ZSZ6
Ensemble ID
ENST00000322038.5
HGNC ID
HGNC:10669

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.V764L .
CAL51 SNV: p.T965I .
EFO27 SNV: p.R411H .
FTC133 SNV: p.C102R .
HCT15 SNV: p.F1046S .
LN18 SNV: p.K998R .
LS123 SNV: p.Y398Ter .
LS180 SNV: p.E539D .
MCC13 SNV: p.S154F; p.S181F; p.Y535F .
NALM6 SNV: p.R230H .
NCIH1155 SNV: p.A945G .
NCIH146 SNV: p.K678E .
NCIH1792 SNV: p.I777L .
NCIH2286 SNV: p.S379L .
SHSY5Y Insertion: p.A155GfsTer69 .
SW1271 SNV: p.P545R .
ZR751 SNV: p.E1073K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C102(0.68)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C102(0.68)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C102(0.97)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C102(0.85)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402