Details of the Target

General Information of Target

Target ID LDTP07827
Target Name Protein phosphatase 1 regulatory subunit 3F (PPP1R3F)
Gene Name PPP1R3F
Gene ID 89801
Synonyms
Protein phosphatase 1 regulatory subunit 3F; R3F
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARTAPVEPPLRHSAPPSPAAGEPRTSVEAAVAPRRVLFADEALGLPLAQLRRYRPWGGP
GAGKMAAAAGQDGGGGGGADEDDDGEDGDEGEEEEEACPEPSPLCPVPAGGGFYLVPTFS
LPPAPGRLERLGRVMVELEALLPPPGAVPGGAGVWVPGGRPPVLRGLVRVLNRSFEKAVH
VRASHDGWASFCDHPARYVPRSPPWAGAGGTGAGDPILDPGLGLGPGQASASSPDDGGRT
DRFAFQLPFAEGAGDGARLDFVVRYETPEGTFWANNHGRNYTVLLRIAPAPTPTDAEGLP
QQQQLPQLEPQPECQGPVEAEARQLKSCMKPVRRRPAEEELKTKNMDDNTFAMAEHPDVQ
ESVGPLVAPTPLRPWPQMTLQVSDVPMTGNPAEEGDVPRSSPPVAFTEVLQAPAIRIPPS
SPLCGLGGSPRDQASGPDASEGATGPFLEPSQQQAEATWGVSSENGGGLEAVSGSEELLG
EDTIDQELEQLYLSHLSRLRAAVAAGGAGGGGEGSTDGGMSPSHPLGILTDRDLILKWPG
PERALNSALAEEITLHYARLGRGVELIKDTEDPDDEGEGEEGLSVTPSSPEGDSPKESPP
EILSGARSVVATMGDVWLPWAEGSGCDGPVVLGTEGQFIGDPEKGMGKDTSSLHMNRVIA
GVTESLGEAGTEAQIEVTSEWAGSLDPISGKEPASPVLLQGQNPTLLSPLGAEVCLSSVA
RPHVSSQDEKDAGPSLEPPKKSPTLAVPAECVCALPPQLRGPLTQTLGVLAGLVVVPVAL
NSGVSLLVLALCLSLAWFS
Target Bioclass
Other
Subcellular location
Membrane
Function Glycogen-targeting subunit for protein phosphatase 1 (PP1).
Uniprot ID
Q6ZSY5
Ensemble ID
ENST00000055335.11
HGNC ID
HGNC:14944

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.S665Y .
CCK81 SNV: p.G527C .
D283MED Deletion: p.L699del .
DU145 SNV: p.A796S .
EFO27 SNV: p.P369S .
KMRC20 SNV: p.E489Q .
LS123 SNV: p.H180P .
MCC13 SNV: p.G159S .
MDAMB453 SNV: p.L128R .
MEWO Substitution: p.R500H .
MV411 Substitution: p.R127C .
NCIH358 SNV: p.G480A; p.E481Ter .
NUGC3 SNV: p.R543Q .
SKN SNV: p.S624Ter .
TE4 SNV: p.E470G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C715(0.95)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C715(0.95)  LDD1507  [1]
 LDCM0276  AC17 HEK-293T C715(0.87)  LDD1515  [1]
 LDCM0285  AC25 HEK-293T C715(1.18)  LDD1524  [1]
 LDCM0294  AC33 HEK-293T C715(0.74)  LDD1533  [1]
 LDCM0303  AC41 HEK-293T C715(0.92)  LDD1542  [1]
 LDCM0311  AC49 HEK-293T C715(1.22)  LDD1550  [1]
 LDCM0320  AC57 HEK-293T C715(0.96)  LDD1559  [1]
 LDCM0356  AKOS034007680 HEK-293T C715(1.01)  LDD1570  [1]
 LDCM0404  CL17 HEK-293T C715(0.66)  LDD1608  [1]
 LDCM0417  CL29 HEK-293T C715(1.09)  LDD1621  [1]
 LDCM0431  CL41 HEK-293T C715(0.98)  LDD1635  [1]
 LDCM0440  CL5 HEK-293T C715(0.87)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C715(0.90)  LDD1647  [1]
 LDCM0457  CL65 HEK-293T C715(1.37)  LDD1660  [1]
 LDCM0470  CL77 HEK-293T C715(1.05)  LDD1673  [1]
 LDCM0483  CL89 HEK-293T C715(1.04)  LDD1686  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402