General Information of Target

Target ID LDTP07807
Target Name Protein LIAT1 (LIAT1)
Gene Name LIAT1
Gene ID 400566
Synonyms
C17orf97; Protein LIAT1; Ligand of ATE1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METRGPGLAVRAESRRLVGIGPRAPPGRVGLQPSGRLDRRGGAGTMGYKDNDGEEEEREG
GAAGPRGSRLPPITGGASELAKRKVKKKKRKKKTKGSGKGDDKHQSQSLKSQPLSSSFHD
ILSPCKERGPKPEHRQSKVEKKHLPSDSSTVSLPDFAEIENLANRINESLRWDGILADPE
AEKERIRIYKLNRRKRYRCLALKGFHPDPEALKGFHPDPDALKGFHPDPEALKGFHPDPE
ALKGFHPDPEALKGFHPDPEALKGIHPDPEALKGIHPDPEALKGFHPDPEALKGFHPDPE
ALKGFHTDPEALKGFHIDPEALKGFHPDPKALKGFHPDPKALKGFHTDPEALKGFHPDPK
ALKGFHPDPEALKGFHPDPEALKGFHPDPEALKGFHTDPNAEEAPENLPYLSDKDGSSSH
RQPTSKAECPNLCFEGNLTPKLLHSDLAPTLLE
Target Bioclass
Other
Function Participates in nucleolar liquid-liquid phase separation (LLPS) through its N-terminal intrinsically disordered region (IDR). May be involved in ATE1-mediated N-terminal arginylation.
Uniprot ID
Q6ZQX7
Ensemble ID
ENST00000360127.7
HGNC ID
HGNC:33800

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C429(2.33); C433(2.33)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCT 116 C429(2.33); C433(2.33)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C429(1.67); C433(1.67)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C429(1.93); C433(1.93)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.