Details of the Target

General Information of Target

Target ID LDTP07800
Target Name Shieldin complex subunit 3 (SHLD3)
Gene Name SHLD3
Synonyms
FLJ26957; RINN1; Shieldin complex subunit 3; REV7-interacting novel NHEJ regulator 1; Shield complex subunit 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTEVILHYRPCESDPTQLPKIAEKAIQDFPTRPLSRFIPWFPYDGSKLPLRPKRSPPVI
SEEAAEDVKQYLTISEHDAKSHSYDCTVDLLEFQPSLKKQHLTWSHTLKEQTNSGNLGKQ
SEKGKQHKRRSWSISLPSNNCTKNVSPLSKKLQDSLKALNLHSLYRARWTIEHTICNSQT
LEDIWTKLNQIIRHNELPSCNATIQRHLGQIWVFCDIMYCEYVGSLLKGRLALTGKINLF
VHKYGVIFSM
Target Bioclass
Other
Subcellular location
Chromosome
Function
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
Uniprot ID
Q6ZNX1
Ensemble ID
ENST00000510585.3
HGNC ID
HGNC:53826

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K123(0.50)  LDD0274  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270