Details of the Target

General Information of Target

Target ID LDTP07789
Target Name Guanylate-binding protein 6 (GBP6)
Gene Name GBP6
Gene ID 163351
Synonyms
Guanylate-binding protein 6; EC 3.6.5.-; GTP-binding protein 6; GBP-6; Guanine nucleotide-binding protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAG
QNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAV
LLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTV
RDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPT
NDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYV
EAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACE
REAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMES
ISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKA
LTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREH
LLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNL
ADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF
Target Bioclass
Enzyme
Family
TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily
Subcellular location
Cytoplasmic vesicle
Function
Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens, such as bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii. Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii.
Uniprot ID
Q6ZN66
Ensemble ID
ENST00000370456.5
HGNC ID
HGNC:25395

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.S3P .
CAL78 SNV: p.F176I .
HCT15 SNV: p.N16S .
HEC1 Deletion: p.N587MfsTer18 .
HEC1B Deletion: p.N587MfsTer18 .
Ishikawa (Heraklio) 02 ER SNV: p.A339V .
MEWO SNV: p.N599D .
MFE319 SNV: p.W592R .
MOLT4 SNV: p.A498V .
RKO SNV: p.H561R .
SKMEL3 SNV: p.V44A .
SKOV3 SNV: p.Q519Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C248(1.21)  LDD3339  [1]
IA-alkyne
 Probe Info  		C406(0.00); C269(0.00); C310(0.00); C233(0.00)  LDD0162  [2]
W1
 Probe Info  		E562(0.00); H561(0.00)  LDD0236  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 JeKo-1 C248(2.10)  LDD2403  [1]
 LDCM0023  KB03 JeKo-1 C248(2.47)  LDD2820  [1]
 LDCM0024  KB05 NALM-6 C248(1.21)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.