Details of the Target

General Information of Target

Target ID LDTP07773
Target Name Thrombospondin type-1 domain-containing protein 4 (THSD4)
Gene Name THSD4
Gene ID 79875
Synonyms
Thrombospondin type-1 domain-containing protein 4; A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6; ADAMTS-like protein 6; ADAMTSL-6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWG
PWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGAPARAFADHVVSAVRTSVPLHRSRDE
TPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT
DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEA
PIYQLPLTHDQGYPAASSLFHSPETSNNHGVGTHGATQSFSQPARSTAISCIGAYRQYKL
CNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQ
AEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKH
ALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGT
MFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPH
RRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPH
RPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDS
SMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQ
HLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKL
RPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPA
EATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK
PPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERE
SCNPQDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANRQTGFLGSR
Target Bioclass
Enzyme
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN.
Uniprot ID
Q6ZMP0
Ensemble ID
ENST00000261862.8
HGNC ID
HGNC:25835

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.I175M; p.Q282E .
EFO27 Deletion: p.I175LfsTer33 .
FTC133 SNV: p.G210D .
HCT15 SNV: p.A808S; p.V889L .
HT Deletion: p.C370VfsTer23 .
HUH7 SNV: p.N323K .
IGR1 SNV: p.A1002V .
KMCH1 SNV: p.K485Q .
KYSE180 Substitution: p.P79F .
LS180 SNV: p.Q146K .
NCIH1155 SNV: p.Y996Ter; p.C1001Y .
NCIH2172 SNV: p.S130G .
P31FUJ SNV: p.S385N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C991(5.97)  LDD3410  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-375 C991(2.03)  LDD2255  [1]
 LDCM0023  KB03 A-375 C991(3.06)  LDD2672  [1]
 LDCM0024  KB05 RPMI-7951 C991(5.97)  LDD3410  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840