Details of the Target

General Information of Target

Target ID LDTP07770
Target Name Scavenger receptor class A member 5 (SCARA5)
Gene Name SCARA5
Gene ID 286133
Synonyms
Scavenger receptor class A member 5; Scavenger receptor hlg
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENKAMYLHTVSDCDTSSICEDSFDGRSLSKLNLCEDGPCHKRRASICCTQLGSLSALKH
AVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLNESFRDLQLRLLQAPLQAD
LTEQVWKVQDALQNQSDSLLALAGAVQRLEGALWGLQAQAVQTEQAVALLRDRTGQQSDT
AQLELYQLQVESNSSQLLLRRHAGLLDGLARRVGILGEELADVGGVLRGLNHSLSYDVAL
HRTRLQDLRVLVSNASEDTRRLRLAHVGMELQLKQELAMLNAVTEDLRLKDWEHSIALRN
ISLAKGPPGPKGDQGDEGKEGRPGIPGLPGLRGLPGERGTPGLPGPKGDDGKLGATGPMG
MRGFKGDRGPKGEKGEKGDRAGDASGVEAPMMIRLVNGSGPHEGRVEVYHDRRWGTVCDD
GWDKKDGDVVCRMLGFRGVEEVYRTARFGQGTGRIWMDDVACKGTEETIFRCSFSKWGVT
NCGHAEDASVTCNRH
Target Bioclass
Enzyme
Family
SCARA5 family
Subcellular location
Cell membrane
Function
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1). {|HAMAP-Rule:MF_03070}.
Uniprot ID
Q6ZMJ2
Ensemble ID
ENST00000354914.8
HGNC ID
HGNC:28701

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.Q147E .
COLO829 SNV: p.E270K .
DU145 SNV: p.P88H .
HCT15 SNV: p.R288C .
JURKAT SNV: p.L91P .
NALM6 SNV: p.V429M .
NCIH2052 SNV: p.R368P .
OCIAML2 SNV: p.G214C .
SNU1 SNV: p.G453W .
ZR751 SNV: p.G318V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C418(3.08)  LDD2256  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A375.S2 C418(3.08)  LDD2256  [1]
 LDCM0023  KB03 A101D C418(3.49)  LDD2667  [1]
 LDCM0024  KB05 A375.S2 C418(4.19)  LDD3090  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Nucleotide sugar transporter SLC35B4 (SLC35B4) Nucleotide-sugar transporter family Q969S0
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Complement C1q-like protein 4 (C1QL4) . Q86Z23
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
RING finger protein 151 (RNF151) . Q2KHN1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840