Details of the Target
General Information of Target
| Target ID | LDTP07749 | |||||
|---|---|---|---|---|---|---|
| Target Name | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (TPTE2) | |||||
| Gene Name | TPTE2 | |||||
| Gene ID | 93492 | |||||
| Synonyms |
TPIP; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; EC 3.1.3.67; Lipid phosphatase TPIP; TPTE and PTEN homologous inositol lipid phosphatase |
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| 3D Structure | ||||||
| Sequence |
MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYD
SKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFL MDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLR LIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS FYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVF TKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTH SNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME KKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWF NTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK |
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| Target Bioclass |
Enzyme
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| Subcellular location |
Cytoplasm; Endoplasmic reticulum membrane
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| Function | Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.; [Isoform 4]: Shows no phosphoinositide phosphatase activity. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
 |
C285(1.62) | LDD2243 | [1] | |
Competitor(s) Related to This Target