Details of the Target
General Information of Target
| Target ID | LDTP07740 | |||||
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| Target Name | Neuropeptide S receptor (NPSR1) | |||||
| Gene Name | NPSR1 | |||||
| Gene ID | 387129 | |||||
| Synonyms |
GPR154; GPRA; PGR14; Neuropeptide S receptor; G-protein coupled receptor 154; G-protein coupled receptor PGR14; G-protein coupled receptor for asthma susceptibility |
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| 3D Structure | ||||||
| Sequence |
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLF
VFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLV CRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIP TLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIK SKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFN LLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERH EMQILSKPEFI |
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| Target Type |
Patented-recorded
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| Target Bioclass |
GPCR
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| Family |
G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily
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| Subcellular location |
Cytoplasm; Cell membrane
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| Function |
G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C95(2.14) | LDD3352 | [1] | |
Competitor(s) Related to This Target