Details of the Target

General Information of Target

Target ID LDTP07711
Target Name Nephronectin (NPNT)
Gene Name NPNT
Gene ID 255743
Synonyms
EGFL6L; POEM; Nephronectin; Preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVC
QPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYM
LMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASC
PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC
KCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTP
YIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTTIAPA
ASTPPGGITVDNRVQTDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADDEAKDDPGVLVH
SCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGD
LCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGE
KRRGHTGEIGLDDVSLKKGHCSEER
Target Bioclass
Other
Family
Nephronectin family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.
Uniprot ID
Q6UXI9
Ensemble ID
ENST00000305572.12
HGNC ID
HGNC:27405

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 Deletion: p.W520_T526del .
AN3CA SNV: p.K146E .
ICC10 SNV: p.R474G .
KYSE180 SNV: p.Q211Ter .
MEWO SNV: p.G272E .
NCIH1792 SNV: p.T355A .
NCIH661 SNV: p.V170F .
OCIAML2 SNV: p.V417I .
SKMEL2 SNV: p.G282E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C86(1.92)  LDD3373  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX142 C86(2.76); C36(2.29)  LDD2267  [1]
 LDCM0023  KB03 BRX142 C36(2.48)  LDD2684  [1]
 LDCM0024  KB05 OCUG-1 C86(1.92)  LDD3373  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840