Details of the Target

General Information of Target

Target ID LDTP07702
Target Name Peptidase inhibitor 16 (PI16)
Gene Name PI16
Gene ID 221476
Synonyms
CRISP9; PSPBP; Peptidase inhibitor 16; PI-16; Cysteine-rich secretory protein 9; CRISP-9; PSP94-binding protein; CD antigen CD364
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHGSCSFLMLLLPLLLLLVATTGPVGALTDEEKRLMVELHNLYRAQVSPTASDMLHMRWD
EELAAFAKAYARQCVWGHNKERGRRGENLFAITDEGMDVPLAMEEWHHEREHYNLSAATC
SPGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIELLVCNYEPPGNVKGKRPYQEG
TPCSQCPSGYHCKNSLCEPIGSPEDAQDLPYLVTEAPSFRATEASDSRKMGTPSSLATGI
PAFLVTEVSGSLATKALPAVETQAPTSLATKDPPSMATEAPPCVTTEVPSILAAHSLPSL
DEEPVTFPKSTHVPIPKSADKVTDKTKVPSRSPENSLDPKMSLTGARELLPHAQEEAEAE
AELPPSSEVLASVFPAQDKPGELQATLDHTGHTSSKSLPNFPNTSATANATGGRALALQS
SLPGAEGPDKPSVVSGLNSGPGHVWGPLLGLLLLPPLVLAGIF
Target Bioclass
Other
Family
CRISP family
Subcellular location
Secreted
Function May inhibit cardiomyocyte growth.
Uniprot ID
Q6UXB8
Ensemble ID
ENST00000373674.4
HGNC ID
HGNC:21245

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.V133A .
IGR1 SNV: p.G239R .
JURKAT SNV: p.A406T .
MFE319 SNV: p.E81K .
ONS76 SNV: p.P351L .
SKOV3 SNV: p.L28I .
SW756 SNV: p.L252P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C74(3.24)  LDD2361  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hs 839.T C74(3.24)  LDD2361  [1]
 LDCM0023  KB03 Hs 839.T C74(4.03)  LDD2778  [1]
 LDCM0024  KB05 Hs 839.T C74(4.93)  LDD3195  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840