Details of the Target

General Information of Target

Target ID LDTP07690
Target Name Layilin (LAYN)
Gene Name LAYN
Gene ID 143903
Synonyms
Layilin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPGTALQAVLLAVLLVGLRAATGRLLSASDLDLRGGQPVCRGGTQRPCYKVIYFHDTSR
RLNFEEAKEACRRDGGQLVSIESEDEQKLIEKFIENLLPSDGDFWIGLRRREEKQSNSTA
CQDLYAWTDGSISQFRNWYVDEPSCGSEVCVVMYHQPSAPAGIGGPYMFQWNDDRCNMKN
NFICKYSDEKPAVPSREAEGEETELTTPVLPEETQEEDAKKTFKESREAALNLAYILIPS
IPLLLLLVVTTVVCWVWICRKRKREQPDPSTKKQHTIWPSPHQGNSPDLEVYNVIRKQSE
ADLAETRPDLKNISFRVCSGEATPDDMSCDYDNMAVNPSESGFVTLVSVESGFVTNDIYE
FSPDQMGRSKESGWVENEIYGY
Target Bioclass
Other
Subcellular location
Membrane
Function Receptor for hyaluronate.
Uniprot ID
Q6UX15
Ensemble ID
ENST00000375614.7
HGNC ID
HGNC:29471

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C184(5.92)  LDD3310  [1]
IPM
 Probe Info  		C41(0.18)  LDD1702  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C41(0.18)  LDD1702  [2]
 LDCM0022  KB02 COLO792 C184(4.09)  LDD2476  [1]
 LDCM0023  KB03 COLO792 C184(4.29)  LDD2893  [1]
 LDCM0024  KB05 COLO792 C184(5.92)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761