Details of the Target

General Information of Target

Target ID LDTP07623
Target Name Adhesion G-protein coupled receptor D1 (ADGRD1)
Gene Name ADGRD1
Gene ID 283383
Synonyms
GPR133; PGR25; Adhesion G-protein coupled receptor D1; G-protein coupled receptor 133; G-protein coupled receptor PGR25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKLLRLCCWYSWLLLFYYNFQVRGVYSRSQDHPGFQVLASASHYWPLENVDGIHELQDT
TGDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGPEGVTFSFFWKTQGEQSRP
IPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEASFSPPGPYWTHVLFTWKSKEGL
KVYVNGTLSTSDPSGKVSRDYGESNVNLVIGSEQDQAKCYENGAFDEFIIWERALTPDEI
AMYFTAAIGKHALLSSTLPSLFMTSTASPVMPTDAYHPIITNLTEERKTFQSPGVILSYL
QNVSLSLPSKSLSEQTALNLTKTFLKAVGEILLLPGWIALSEDSAVVLSLIDTIDTVMGH
VSSNLHGSTPQVTVEGSSAMAEFSVAKILPKTVNSSHYRFPAHGQSFIQIPHEAFHRHAW
STVVGLLYHSMHYYLNNIWPAHTKIAEAMHHQDCLLFATSHLISLEVSPPPTLSQNLSGS
PLITVHLKHRLTRKQHSEATNSSNRVFVYCAFLDFSSGEGVWSNHGCALTRGNLTYSVCR
CTHLTNFAILMQVVPLELARGHQVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQ
RYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSM
VIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPA
LFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAV
NGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTSNAKPFH
SDLMNGTRPGMASTKLSPWDKSSHSAHRVDLSAV
Target Bioclass
GPCR
Family
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Subcellular location
Cell membrane
Function Orphan receptor. Signals via G(s)-alpha family of G-proteins. Has protumorigenic function especially in glioblastoma.
Uniprot ID
Q6QNK2
Ensemble ID
ENST00000261654.10
HGNC ID
HGNC:19893
ChEMBL ID
CHEMBL4523877

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.S92C .
CCK81 SNV: p.R848W .
EGI1 SNV: p.R601H .
HCT116 SNV: p.V361A .
HCT15 SNV: p.I713V .
Ishikawa (Heraklio) 02 ER SNV: p.K822N .
KASUMI1 SNV: p.T700A .
KMS12BM SNV: p.E286K .
KPL1 SNV: p.Q37H .
MCC13 SNV: p.G359S .
MCF7 SNV: p.Q37H .
NCIH1048 SNV: p.P97S .
NCIH1299 SNV: p.N90K .
SKNSH SNV: p.H867P .
SNGM SNV: p.L305I .
VCAP Substitution: p.T758M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264