Details of the Target
General Information of Target
| Target ID | LDTP07619 | |||||
|---|---|---|---|---|---|---|
| Target Name | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 (DEGS2) | |||||
| Gene Name | DEGS2 | |||||
| Gene ID | 123099 | |||||
| Synonyms |
C14orf66; Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; EC 1.14.18.5; EC 1.14.19.17; Degenerative spermatocyte homolog 2; Sphingolipid 4-desaturase; Sphingolipid C4-monooxygenase |
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| 3D Structure | ||||||
| Sequence |
MGNSASRSDFEWVYTDQPHTQRRKEILAKYPAIKALMRPDPRLKWAVLVLVLVQMLACWL
VRGLAWRWLLFWAYAFGGCVNHSLTLAIHDISHNAAFGTGRAARNRWLAVFANLPVGVPY AASFKKYHVDHHRYLGGDGLDVDVPTRLEGWFFCTPARKLLWLVLQPFFYSLRPLCVHPK AVTRMEVLNTLVQLAADLAIFALWGLKPVVYLLASSFLGLGLHPISGHFVAEHYMFLKGH ETYSYYGPLNWITFNVGYHVEHHDFPSIPGYNLPLVRKIAPEYYDHLPQHHSWVKVLWDF VFEDSLGPYARVKRVYRLAKDGL |
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| Target Bioclass |
Enzyme
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| Family |
Fatty acid desaturase type 1 family, DEGS subfamily
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function | Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
NAIA_5 Probe Info |
 |
N.A. | LDD2224 | [1] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STS-2 Probe Info |
 |
N.A. | LDD0138 | [2] | |
References