Details of the Target

General Information of Target

Target ID LDTP07616
Target Name Aminopeptidase Q (LVRN)
Gene Name LVRN
Gene ID 206338
Synonyms
AQPEP; Aminopeptidase Q; AP-Q; APQ; EC 3.4.11.-; CHL2 antigen; Laeverin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPPSSSGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSP
PLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDEL
PAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVW
FALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLE
PTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTT
PHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFN
ISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQ
WFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTR
AVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQ
DDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKN
RTLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRV
NYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEI
IVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLA
LISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWD
ILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVASSEV
GRYVAKDFLVNNWQAVSKRYGTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIR
VHANLQTIKNENLKNKKLSARIAAWLRRNT
Target Bioclass
Enzyme
Family
Peptidase M1 family
Subcellular location
Membrane
Function
Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.
Uniprot ID
Q6Q4G3
Ensemble ID
ENST00000357872.9
HGNC ID
HGNC:26904
ChEMBL ID
CHEMBL3831223

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II SNV: p.P821S .
CAL51 SNV: p.P161L .
EFO21 SNV: p.I932K .
EFO27 Insertion: p.C153NfsTer47
SNV: p.D152H		 .
FADU SNV: p.A983G .
HT115 SNV: p.E157K; p.N565H .
IPC298 SNV: p.D357N .
KASUMI2 SNV: p.V32I .
KMCH1 SNV: p.N729K .
LN18 SNV: p.L756I .
LUDLU1 SNV: p.S200G .
MCC13 SNV: p.Y594N .
NCIH23 SNV: p.G418A .
NUGC3 SNV: p.V176M .
PF382 SNV: p.Y535H .
REH SNV: p.R155H .
SKMEL3 SNV: p.R130H .
SNGM SNV: p.G8C .
SW403 SNV: p.A122D .
TE8 SNV: p.V634I .
UMUC3 SNV: p.D53N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C250(1.06)  LDD2284  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CAL-120 C250(1.06)  LDD2284  [1]
 LDCM0023  KB03 CAL-51 C250(1.62)  LDD2705  [1]
 LDCM0024  KB05 CAL-120 C250(1.34)  LDD3118  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840