General Information of Target

Target ID LDTP07595
Target Name T-cell receptor-associated transmembrane adapter 1 (TRAT1)
Gene Name TRAT1
Gene ID 50852
Synonyms
TCRIM; T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; TRIM; pp29/30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGISGCPFFLWGLLALLGLALVISLIFNISHYVEKQRQDKMYSYSSDHTRVDEYYIEDT
PIYGNLDDMISEPMDENCYEQMKARPEKSVNKMQEATPSAQATNETQMCYASLDHSVKGK
RRKPRKQNTHFSDKDGDEQLHAIDASVSKTTLVDSFSPESQAVEENIHDDPIRLFGLIRA
KREPIN
Target Bioclass
Other
Subcellular location
Cell membrane
Function Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
Uniprot ID
Q6PIZ9
Ensemble ID
ENST00000295756.11
HGNC ID
HGNC:30698

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info 
C109(2.00)  LDD0304  [1]
Lodoacetamide azide
 Probe Info 
N.A.  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0131  RA190 MM1.R C109(2.00)  LDD0304  [1]

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853