Details of the Target

General Information of Target

Target ID LDTP07584
Target Name INO80 complex subunit C (INO80C)
Gene Name INO80C
Gene ID 125476
Synonyms
C18orf37; INO80 complex subunit C; IES6 homolog; hIes6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAQIPIVATTSTPGIVRNSKKRPASPSHNGSSGGGYGASKKKKASASSFAQGISMEAMS
ENKMVPSEFSTGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILASERALPW
QLNDPNYFSIDAPPSFKPAKKYSDVSGLLANYTDPQSKLRFSTIEEFSYIRRLPSDVVTG
YLALRKATSIVP
Target Bioclass
Other
Subcellular location
Nucleus
Function Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Uniprot ID
Q6PI98
Ensemble ID
ENST00000334598.12
HGNC ID
HGNC:26994

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P192S .
HGC27 SNV: p.G36D .
LU65 SNV: p.V17L .
MFE319 SNV: p.E115K .
SW620 SNV: p.Y127S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y169(11.39)  LDD0257  [1]
STPyne
 Probe Info  		K109(1.56)  LDD0277  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serpin H1 (SERPINH1) Serpin family P50454

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270