Details of the Target
General Information of Target
| Target ID | LDTP07570 | |||||
|---|---|---|---|---|---|---|
| Target Name | tRNA methyltransferase 10 homolog B (TRMT10B) | |||||
| Gene Name | TRMT10B | |||||
| Gene ID | 158234 | |||||
| Synonyms |
RG9MTD3; tRNA methyltransferase 10 homolog B; EC 2.1.1.221; RNA; guanine-9-)-methyltransferase domain-containing protein 3; tRNA; guanine(9)-N(1))-methyltransferase TRMT10B |
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| 3D Structure | ||||||
| Sequence |
MDWKLEGSTQKVESPVLQGQEGILEETGEDGLPEGFQLLQIDAEGECQEGEILATGSTAW
CSKNVQRKQRHWEKIVAAKKSKRKQEKERRKANRAENPGICPQHSKRFLRALTKDKLLEA KHSGPRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEEC VRMNDGFSSYLLDITEEDCFSLFPLETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQK KVTFQKAREYSVKTARLPIQEYMVRNQNGKNYHSEILAINQVFDILSTYLETHNWPEALK KGVSSGKGYILRNSVE |
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| Target Bioclass |
Enzyme
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| Family |
Class IV-like SAM-binding methyltransferase superfamily, TRM10 family
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| Function |
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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N.A. | LDD2156 | [1] | |