Details of the Target

General Information of Target

Target ID LDTP07557
Target Name von Willebrand factor A domain-containing protein 1 (VWA1)
Gene Name VWA1
Gene ID 64856
Synonyms
von Willebrand factor A domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPWTALGLALSLRLALARSGAERGPPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQL
VAPLPLGTGALRASLVHVGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDTHTGLALVYA
KEQLFAEASGARPGVPKVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSA
AASAPAEKHLHFVDVDDLHIIVQELRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADS
GYYVLELVPSAQPGAARRQQLPGNATDWIWAGLDPDTDYDVALVPESNVRLLRPQILRVR
TRPGEAGPGASGPESGAGPAPTQLAALPAPEEAGPERIVISHARPRSLRVSWAPALGSAA
ALGYHVQFGPLRGGEAQRVEVPAGRNCTTLQGLAPGTAYLVTVTAAFRSGRESALSAKAC
TPDGPRPRPRPVPRAPTPGTASREP
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function Promotes matrix assembly. Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (Probable).
Uniprot ID
Q6PCB0
Ensemble ID
ENST00000338660.5
HGNC ID
HGNC:30910

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.R258C .
HGC27 SNV: p.A343T .
IGROV1 SNV: p.V78M .
KU1919 SNV: p.T277M .
LS180 SNV: p.G373D .
MCC13 Substitution: p.P154L .
OCUG1 SNV: p.D280G .
RL SNV: p.T277M .
SG231 SNV: p.D267V .
SNGM Insertion: p.M155HfsTer43 .
SNU869 SNV: p.E187Q .
UACC257 SNV: p.L273F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C420(0.86)  LDD1492  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C420(0.86)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C420(1.23)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C420(0.96)  LDD1502  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402