Details of the Target

General Information of Target

Target ID LDTP07553
Target Name E3 ubiquitin ligase TRIM40 (TRIM40)
Gene Name TRIM40
Gene ID 135644
Synonyms
RNF35; E3 ubiquitin ligase TRIM40; EC 2.3.2.27; Probable E3 NEDD8-protein ligase; RING finger protein 35
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIPLQKDNQEEGVCPICQESLKEAVSTNCGHLFCRVCLTQHVEKASASGVFCCPLCRKPC
SEEVLGTGYICPNHQKRVCRFCEESRLLLCVECLVSPEHMSHHELTIENALSHYKERLNR
RSRKLRKDIAELQRLKAQQEKKLQALQFQVDHGNHRLEAGPESQHQTREQLGALPQQWLG
QLEHMPAEAARILDISRAVTQLRSLVIDLERTAKELDTNTLKNAGDLLNRSAPQKLEVIY
PQLEKGVSELLLQPPQKL
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Function
E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation.
Uniprot ID
Q6P9F5
Ensemble ID
ENST00000307859.4
HGNC ID
HGNC:18736

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.P3L .
OCILY3 SNV: p.S112G .
SH4 SNV: p.P54L .
SUPT1 SNV: p.S163I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K127(10.00)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270