Details of the Target
General Information of Target
| Target ID | LDTP07548 | |||||
|---|---|---|---|---|---|---|
| Target Name | Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) | |||||
| Gene Name | NOTUM | |||||
| Gene ID | 147111 | |||||
| Synonyms |
Palmitoleoyl-protein carboxylesterase NOTUM; EC 3.1.1.98; hNOTUM |
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| 3D Structure | ||||||
| Sequence |
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVE
GNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRW LLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFI PYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLL NVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNG VVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGL RLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHD SHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQP QGLEPSELLGMLSNGS |
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| Target Bioclass |
Enzyme
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| Family |
Pectinacetylesterase family, Notum subfamily
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| Subcellular location |
Secreted
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| Function |
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C80(3.10) | LDD3402 | [1] | |
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IA-alkyne Probe Info |
 |
N.A. | LDD0032 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References