Details of the Target

General Information of Target

Target ID LDTP07528
Target Name DnaJ homolog subfamily C member 24 (DNAJC24)
Gene Name DNAJC24
Gene ID 120526
Synonyms
DPH4; ZCSL3; DnaJ homolog subfamily C member 24; CSL-type zinc finger-containing protein 3; Diphthamide biosynthesis protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMAVEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFI
EIDQAWKILGNEETKREYDLQRCEDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGK
YSVSKDEAEEVSLISCDTCSLIIELLHYN
Target Bioclass
Other
Family
DPH4 family
Subcellular location
Cytoplasm, cytoskeleton
Function
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
Uniprot ID
Q6P3W2
Ensemble ID
ENST00000465995.6
HGNC ID
HGNC:26979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1187 Deletion: p.S103EfsTer2 .
LN18 SNV: p.D26Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C55(2.79)  LDD3408  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C55(0.79)  LDD1520  [2]
 LDCM0289  AC29 HEK-293T C55(0.93)  LDD1528  [2]
 LDCM0298  AC37 HEK-293T C55(1.28)  LDD1537  [2]
 LDCM0307  AC45 HEK-293T C55(0.97)  LDD1546  [2]
 LDCM0312  AC5 HEK-293T C55(0.98)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C55(1.10)  LDD1555  [2]
 LDCM0325  AC61 HEK-293T C55(1.19)  LDD1564  [2]
 LDCM0248  AKOS034007472 HEK-293T C55(1.05)  LDD1511  [2]
 LDCM0409  CL21 HEK-293T C55(1.39)  LDD1613  [2]
 LDCM0422  CL33 HEK-293T C55(0.91)  LDD1626  [2]
 LDCM0435  CL45 HEK-293T C55(1.21)  LDD1639  [2]
 LDCM0448  CL57 HEK-293T C55(1.19)  LDD1651  [2]
 LDCM0461  CL69 HEK-293T C55(1.52)  LDD1664  [2]
 LDCM0475  CL81 HEK-293T C55(1.68)  LDD1678  [2]
 LDCM0484  CL9 HEK-293T C55(1.30)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C55(1.63)  LDD1691  [2]
 LDCM0022  KB02 A3-KAW C55(2.77)  LDD2257  [1]
 LDCM0023  KB03 A3-KAW C55(1.40)  LDD2674  [1]
 LDCM0024  KB05 RL C55(2.79)  LDD3408  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402