Details of the Target

General Information of Target

Target ID LDTP07488
Target Name Protein phosphatase inhibitor 2 family member B (PPP1R2B)
Gene Name PPP1R2B
Synonyms
PPP1R2P3; Protein phosphatase inhibitor 2 family member B; PPP1R2 family member B; Protein phosphatase 1, regulatory subunit 2 pseudogene 3; Protein phosphatase inhibitor 2-like protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASTASHRPIKGILKNKTSTTSSMVASAEQPRRSVDEELSKKSQKWDEINILATYHPAD
KGYGLMKIDEPSPPYHSMMGDDEDACRDTETTEAMAPDILAKKLAAAEGLEPKYRIQEQE
SSGEEDSDLSPEEREKKRQFEMRRKLHYNEGLNIKLARQLISKDLHDDDEDEEMLETADG
ESMNTEESNQGSTPSDQQQNKLRSS
Target Bioclass
Enzyme
Family
Protein phosphatase inhibitor 2 family
Function Inhibitor of protein-phosphatase 1.
Uniprot ID
Q6NXS1
Ensemble ID
ENST00000522232.3
HGNC ID
HGNC:16318

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K145(0.84)  LDD0277  [1]
HHS-475
 Probe Info  		Y148(0.81)  LDD0264  [2]
Acrolein
 Probe Info  		N.A.  LDD0226  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
HHS-465
 Probe Info  		N.A.  LDD2240  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y148(0.81)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y148(0.64)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y148(0.71)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y148(0.71)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y148(0.83)  LDD0268  [2]
 LDCM0109  NEM HeLa N.A.  LDD0226  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) PPP phosphatase family P62140
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2B type W-T (H2BW1) Histone H2B family Q7Z2G1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010