Details of the Target
General Information of Target
| Target ID | LDTP07459 | |||||
|---|---|---|---|---|---|---|
| Target Name | Myogenesis-regulating glycosidase (MYORG) | |||||
| Gene Name | MYORG | |||||
| Gene ID | 57462 | |||||
| Synonyms |
KIAA1161; Myogenesis-regulating glycosidase; EC 3.2.1.-; Uncharacterized family 31 glucosidase KIAA1161 |
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| 3D Structure | ||||||
| Sequence |
MLQNPQEKSQAYPRRRRPGCYAYRQNPEAIAAAAMYTFLPDNFSPAKPKPSKDLKPLLGS
AVLGLLLVLAAVVAWCYYSVSLRKAERLRAELLDLKAGGFSIRNQKGEQVFRLAFRSGAL DLDSCSRDGALLGCSLTADGLPLHFFIQTVRPKDTVMCYRVRWEEAAPGRAVEHAMFLGD AAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSDAAFGGILERYWLSSRAAAIKVN DSVPFHLGWNSTERSLRLQARYHDTPYKPPAGRAAAPELSYRVCVGSDVTSIHKYMVRRY FNKPSRVPAPEAFRDPIWSTWALYGRAVDQDKVLRFAQQIRLHHFNSSHLEIDDMYTPAY GDFDFDEVKFPNASDMFRRLRDAGFRVTLWVHPFVNYNSSRFGEGVERELFVREPTGRLP ALVRWWNGIGAVLDFTHPKARDWFQGHLRRLRSRYSVASFKFDAGEVSYLPRDFSTYRPL PDPSVWSRRYTEMALPFFSLAEVRVGYQSQNISCFFRLVDRDSVWGYDLGLRSLIPAVLT VSMLGYPFILPDMVGGNAVPQRTAGGDVPERELYIRWLEVAAFMPAMQFSIPPWRYDAEV VAIAQKFAALRASLVAPLLLELAGEVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTL LVAPVLEPGKQERDVYLPAGKWRSYKGELFDKTPVLLTDYPVDLDEIAYFTWAS |
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| Target Bioclass |
Enzyme
|
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| Family |
Glycosyl hydrolase 31 family
|
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| Subcellular location |
Nucleus membrane
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| Function | Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
YN-1 Probe Info |
 |
100.00 | LDD0444 | [1] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0163 | [2] | |
References