Details of the Target

General Information of Target

Target ID LDTP07408
Target Name Sesquipedalian-2 (PHETA2)
Gene Name PHETA2
Gene ID 150368
Synonyms
FAM109B; Sesquipedalian-2; Ses2; 27 kDa inositol polyphosphate phosphatase interacting protein B; IPIP27B; PH domain-containing endocytic trafficking adaptor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLNERSVAHYALSDSPADHMGFLRTWGGPGTPPTPSGTGRRCWFVLKGNLLFSFESREG
RAPLSLVVLEGCTVELAEAPVPEEFAFAICFDAPGVRPHLLAAEGPAAQEAWVKVLSRAS
FGYMRLVVRELESQLQDARQSLALQRRSSWKSVASRCKPQAPNHRAAGLENGHCLSKDSS
PVGLVEEAGSRSAGWGLAEWELQGPASLLLGKGQSPVSPETSCFSTLHDWYGQEIVELRQ
CWQKRAQGSHSKCEEQDRP
Target Bioclass
Other
Family
Sesquipedalian family
Subcellular location
Early endosome
Function Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
Uniprot ID
Q6ICB4
Ensemble ID
ENST00000321753.8
HGNC ID
HGNC:27161

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C157(4.32)  LDD3352  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C253(2.36)  LDD2250  [1]
 LDCM0023  KB03 A101D C253(2.14)  LDD2667  [1]
 LDCM0024  KB05 NCI-H1975 C157(4.32)  LDD3352  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Clavesin-2 (CLVS2) . Q5SYC1
Pleckstrin homology domain-containing family J member 1 (PLEKHJ1) . Q9NW61

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255