Details of the Target

General Information of Target

Target ID LDTP07395
Target Name Actin-binding LIM protein 2 (ABLIM2)
Gene Name ABLIM2
Gene ID 84448
Synonyms
KIAA1808; Actin-binding LIM protein 2; abLIM-2; Actin-binding LIM protein family member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAVSQPQAAPSPLEKSPSTAILCNTCGNVCKGEVLRVQDKYFHIKCFVCKACGCDLAEG
GFFVRQGEYICTLDYQRLYGTRCFSCDQFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGD
RVTFNGKECMCQKCSLPVSVGSSAHLSQGLRSCGGCGTEIKNGQALVALDKHWHLGCFKC
KSCGKLLNAEYISKDGLPYCEADYHAKFGIRCDSCEKYITGRVLEAGEKHYHPSCALCVR
CGQMFAEGEEMYLQGSSIWHPACRQAARTEDRNKETRTSSESIISVPASSTSGSPSRVIY
AKLGGEILDYRDLAALPKSKAIYDIDRPDMISYSPYISHSAGDRQSYGEGDQDDRSYKQC
RTSSPSSTGSVSLGRYTPTSRSPQHYSRPGSESGRSTPSLSVLSDSKPPPSTYQQAPRHF
HVPDTGVKDNIYRKPPIYRQHAARRSDGEDGSLDQDNRKKSSWLMLKGDADTRTNSPDLD
TQSLSHSSGTDRDPLQRMAGDSFHSRFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDAS
WGMREYKIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWK
RNDLKKKALLF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
Uniprot ID
Q6H8Q1
Ensemble ID
ENST00000341937.9
HGNC ID
HGNC:19195

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C71(1.22)  LDD3331  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CCK-81 C200(1.03); C71(1.03)  LDD2297  [1]
 LDCM0023  KB03 A2780 C71(1.22)  LDD2671  [1]
 LDCM0024  KB05 MKN-1 C71(1.22)  LDD3331  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Prelamin-A/C (LMNA) Intermediate filament family P02545
Merlin (NF2) . P35240
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.