Details of the Target

General Information of Target

Target ID LDTP07369
Target Name Putative histone H2B type 2-C (H2BC20P)
Gene Name H2BC20P
Synonyms
HIST2H2BC; Putative histone H2B type 2-C; H2B-clustered histone 20 pseudogene; Histone H2B.t; H2B/t
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEPAKFAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKRVHPDTGIWCKAM
GIMNSFLNDIFERIAGEASRLAHYNKRSTITSRRSRRPCACCCPASWPSTPCPRAPRRSP
STPAPSESLPGPGARSLPPSLPPRVAGCFVSKGSFQGHLTTSVKESFLCCQSQLMFLASR
LVNFRRAHNTKHR
Target Bioclass
Other
Family
Histone H2B family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q6DN03
HGNC ID
HGNC:20516

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y84(1.13)  LDD0264  [2]
HHS-465
 Probe Info  		Y84(2.95)  LDD2237  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y84(1.13)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y84(1.00)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y84(1.27)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y84(1.26)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y84(1.74)  LDD0268  [2]

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.