Details of the Target

General Information of Target

Target ID LDTP07358
Target Name Fc receptor-like B (FCRLB)
Gene Name FCRLB
Gene ID 127943
Synonyms
FCRL2; FCRLM2; FCRY; FREB2; Fc receptor-like B; Fc receptor homolog expressed in B-cells protein 2; FREB-2; Fc receptor-like and mucin-like protein 2; Fc receptor-like protein 2; Fc receptor-related protein Y; FcRY
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWPLTALLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTL
WYLGHLLLPSHKKSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPL
VLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIPVESAP
MFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYS
RAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDPASTTAP
APWAAALAPGNRPLSFRKPPVSRSVPLVTSVRNTTSTGLQFPASGAPTAGPPACAPPTPL
EQSAGALKPDVDLLLREMQLLKGLLSRVVLELKEPQALRELRGTPETPTSHFAVSPGTPE
TTPVES
Target Bioclass
Immunoglobulin
Subcellular location
Cytoplasm
Uniprot ID
Q6BAA4
Ensemble ID
ENST00000336830.9
HGNC ID
HGNC:26431

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.D370V .
HT115 SNV: p.F182L .
MELJUSO SNV: p.Y128D .
NCIH1155 SNV: p.G287V .
REH SNV: p.R88Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C168(3.62)  LDD2413  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Karpas-422 C168(3.62)  LDD2413  [1]
 LDCM0023  KB03 Karpas-422 C168(4.42)  LDD2830  [1]
 LDCM0024  KB05 Karpas-422 C168(4.32)  LDD3247  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840