Details of the Target

General Information of Target

Target ID LDTP07355
Target Name E3 ubiquitin-protein ligase TRIM68 (TRIM68)
Gene Name TRIM68
Gene ID 55128
Synonyms
GC109; RNF137; SS56; E3 ubiquitin-protein ligase TRIM68; EC 2.3.2.27; RING finger protein 137; RING-type E3 ubiquitin transferase TRIM68; SSA protein SS-56; SS-56; Tripartite motif-containing protein 68
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC
RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEAC
SQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETR
KQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQV
LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKT
YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW
EVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPP
RRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICS
LDGED
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Cytoplasm, perinuclear region
Function Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
Uniprot ID
Q6AZZ1
Ensemble ID
ENST00000300747.10
HGNC ID
HGNC:21161

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.V79G .
CCK81 SNV: p.I396M .
JURKAT SNV: p.F341I .
KYSE410 SNV: p.Q204H .
MEWO SNV: p.L205V .
NCIH1703 SNV: p.L476V .
NCIH196 SNV: p.E150Ter .
OCUG1 SNV: p.E111D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C73(2.37)  LDD3339  [1]
SF
 Probe Info  		N.A.  LDD0028  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C73(1.23)  LDD2250  [1]
 LDCM0023  KB03 DEL C73(2.11)  LDD2732  [1]
 LDCM0024  KB05 NALM-6 C73(2.37)  LDD3339  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Tudor-interacting repair regulator protein (NUDT16L1) Nudix hydrolase family Q9BRJ7
E3 ubiquitin-protein ligase TRIM68 (TRIM68) TRIM/RBCC family Q6AZZ1
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Leucine zipper transcription factor-like protein 1 (LZTFL1) LZTFL1 family Q9NQ48
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931