Details of the Target

General Information of Target

Target ID LDTP07336
Target Name Microtubule-associated tyrosine carboxypeptidase 1 (MATCAP1)
Gene Name MATCAP1
Gene ID 653319
Synonyms
KIAA0895L; MATCAP; Microtubule-associated tyrosine carboxypeptidase 1; EC 3.4.17.17; Microtubule-associated tyrosine carboxypeptidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQSLALPLALAVPPALQPQ
PEQQPFSQMLLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPPGRGRNPGGGTLRPAASLP
HIAKTQRDAGHIASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKY
CEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCAGEVV
VQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNARQPWHNA
EGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLERY
VQDADVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGIVRILRHRQTIDFPLLTSLGKVSY
EDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMATNRLDEAELGRLLPD
Target Bioclass
Enzyme
Family
Peptidase MATCAP family
Subcellular location
Cytoplasm, cytoskeleton
Function
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8. Recognizes adjacent tubulin dimers along the same protofilament.
Uniprot ID
Q68EN5
Ensemble ID
ENST00000290881.11
HGNC ID
HGNC:34408

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 Deletion: p.V141del .
RKO Deletion: p.S16AfsTer13 .
SKMEL2 SNV: p.P17S .
SNU869 SNV: p.A374S .
TE4 SNV: p.D32H .
TOV21G SNV: p.G103Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0225  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0225  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 8B (ZBTB8B) . Q8NAP8

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.