Details of the Target
General Information of Target
| Target ID | LDTP07310 | |||||
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| Target Name | Acyl-coenzyme A synthetase ACSM2B, mitochondrial (ACSM2B) | |||||
| Gene Name | ACSM2B | |||||
| Gene ID | 348158 | |||||
| Synonyms |
ACSM2; Acyl-coenzyme A synthetase ACSM2B, mitochondrial; EC 6.2.1.2; Acyl-CoA synthetase medium-chain family member 2B; Benzoate--CoA ligase; EC 6.2.1.25; Butyrate--CoA ligase 2B; Butyryl-coenzyme A synthetase 2B; Middle-chain acyl-CoA synthetase 2B; Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A
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| 3D Structure | ||||||
| Sequence |
MHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKA
GKRLPSPALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWW LVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIK LLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGL KAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPKFDPLVILKTL SSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREF YGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEGDIGIRVKPIRPI GIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVEN ALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQHVKSVTAPYKY PRKIEFVLNLPKTVTGKIQRTKLRDKEWKMSGKARAQ |
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| Target Bioclass |
Enzyme
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| Family |
ATP-dependent AMP-binding enzyme family
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| Subcellular location |
Mitochondrion
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| Function |
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C188(2.83) | LDD3424 | [1] | |
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CY-1 Probe Info |
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N.A. | LDD0246 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References