Details of the Target

General Information of Target

Target ID LDTP07302
Target Name Autophagy-related protein 9B (ATG9B)
Gene Name ATG9B
Gene ID 285973
Synonyms
APG9L2; NOS3AS; Autophagy-related protein 9B; APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSRMGWGGRRRRLGRWGDLGPGSVPLLPMPLPPPPPPSCRGPGGGRISIFSLSPAPHTR
SSPSSFSPPTAGPPCSVLQGTGASQSCHSALPIPATPPTQAQPAMTPASASPSWGSHSTP
PLAPATPTPSQQCPQDSPGLRVGPLIPEQDYERLEDCDPEGSQDSPIHGEEQQPLLHVPE
GLRGSWHHIQNLDSFFTKIYSYHQRNGFACILLEDVFQLGQFIFIVTFTTFLLRCVDYNV
LFANQPSNHTRPGPFHSKVTLSDAILPSAQCAERIRSSPLLVLLLVLAAGFWLVQLLRSV
CNLFSYWDIQVFYREALHIPPEELSSVPWAEVQSRLLALQRSGGLCVQPRPLTELDIHHR
ILRYTNYQVALANKGLLPARCPLPWGGSAAFLSRGLALNVDLLLFRGPFSLFRGGWELPH
AYKRSDQRGALAARWGRTVLLLAALNLALSPLVLAWQVLHVFYSHVELLRREPGALGARG
WSRLARLQLRHFNELPHELRARLARAYRPAAAFLRTAAPPAPLRTLLARQLVFFAGALFA
ALLVLTVYDEDVLAVEHVLTAMTALGVTATVARSFIPEEQCQGRAPQLLLQTALAHMHYL
PEEPGPGGRDRAYRQMAQLLQYRAVSLLEELLSPLLTPLFLLFWFRPRALEIIDFFHHFT
VDVAGVGDICSFALMDVKRHGHPQWLSAGQTEASLSQRAEDGKTELSLMRFSLAHPLWRP
PGHSSKFLGHLWGRVQQDAAAWGATSARGPSTPGVLSNCTSPLPEAFLANLFVHPLLPPR
DLSPTAPCPAAATASLLASISRIAQDPSSVSPGGTGGQKLAQLPELASAEMSLHVIYLHQ
LHQQQQQQEPWGEAAASILSRPCSSPSQPPSPDEEKPSWSSDGSSPASSPRQQWGTQKAR
NLFPGGFQVTTDTQKEPDRASCTD
Target Bioclass
Transporter and channel
Family
ATG9 family
Subcellular location
Preautophagosomal structure membrane
Function
Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. In addition to autophagy, also plays a role in necrotic cell death.
Uniprot ID
Q674R7
Ensemble ID
ENST00000469530.4
HGNC ID
HGNC:21899

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CFPAC1 SNV: p.R360S .
COLO792 SNV: p.S113F .
DU145 SNV: p.P321Q .
FADU SNV: p.P775R .
HCT116 SNV: p.C863R .
HCT15 SNV: p.G414W .
HL60 SNV: p.T96P .
HLF SNV: p.G46V .
IGR1 SNV: p.E315K .
IGROV1 Deletion: p.S67PfsTer39 .
IPC298 Substitution: p.P775S .
Ishikawa (Heraklio) 02 ER SNV: p.S889N .
JURKAT SNV: p.S795N .
LS180 SNV: p.G729V .
MEWO SNV: p.L797I .
MM1S SNV: p.A699S .
NCIH358 Insertion: p.E322GfsTer143 .
OVCAR8 SNV: p.L175Q .
SAOS2 SNV: p.R11S .
SW1271 SNV: p.S751F .
TOV21G Deletion: p.P721QfsTer62
SNV: p.R679L		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264