Details of the Target
General Information of Target
| Target ID | LDTP07288 | |||||
|---|---|---|---|---|---|---|
| Target Name | Putative methyltransferase NSUN5C (NSUN5P2) | |||||
| Gene Name | NSUN5P2 | |||||
| Synonyms |
NSUN5C; WBSCR20B; WBSCR20C; Putative methyltransferase NSUN5C; EC 2.1.1.-; NOL1/NOP2/Sun domain family member 5C; Williams-Beuren syndrome chromosomal region 20C protein |
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| 3D Structure | ||||||
| Sequence |
MPELLVFPAQTDLHEHPLYRAGHLILQDRASCLPAMLLDPRQAPMSWMPVPPQAIKTSHL
AALLKNQGKIFAFDLDARRLASMATLLAWAGVSCCELAEEDFLAVSPLDPRYREVHYVLL DPSCSGSGMPSRQLEEPGAGTPSPVRLHALAGFQQRALCHALTFPSLQRLVYSMCSLCQE ENEDMVQDALQQNPGAFRLAPALPARPHRGLSTFPGAEHCLRASPKTTLSGGFFVAVIER VEMPTSASQAKASAPERTPSPAPKRKKRAKSCSRCLHTALHIAEAPGSLLPGGKGRCLSS PWKTLGPHRRQQFAF |
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| Target Bioclass |
Enzyme
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| Family |
Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
|
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| Function | May have S-adenosyl-L-methionine-dependent methyl-transferase activity. | |||||
| Uniprot ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K264(10.00) | LDD0277 | [1] | |
|
BTD Probe Info |
 |
C159(1.30) | LDD2117 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C159(1.30) | LDD2117 | [2] |
| LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C159(1.12) | LDD2123 | [2] |
| LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C220(1.30) | LDD2136 | [2] |
| LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C159(1.35) | LDD2137 | [2] |
References