Details of the Target

General Information of Target

Target ID LDTP07253
Target Name UL16-binding protein 6 (RAET1L)
Gene Name RAET1L
Gene ID 154064
Synonyms
ULBP6; UL16-binding protein 6; Retinoic acid early transcript 1L protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT
FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT
LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM
SFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC
FILPGI
Target Bioclass
Other
Family
MHC class I family
Subcellular location
Cell membrane
Function Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Uniprot ID
Q5VY80
Ensemble ID
ENST00000286380.2
HGNC ID
HGNC:16798

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [1]

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853