Details of the Target
General Information of Target
| Target ID | LDTP07252 | |||||
|---|---|---|---|---|---|---|
| Target Name | Platelet endothelial aggregation receptor 1 (PEAR1) | |||||
| Gene Name | PEAR1 | |||||
| Gene ID | 375033 | |||||
| Synonyms |
MEGF12; Platelet endothelial aggregation receptor 1; hPEAR1; Multiple epidermal growth factor-like domains protein 12; Multiple EGF-like domains protein 12 |
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| 3D Structure | ||||||
| Sequence |
MSPPLCPLLLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCERPWE
GPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQC QCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTP GYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGV FQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGD RCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQ APCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATS GLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVP CPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCD HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPG FRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGEN CAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPET GACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRH WQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNKVPG PLFASLQNPERPGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGP FYNKGLISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQ FWDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYD LPPVRHPPSPPLRRQDR |
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| Target Bioclass |
Other
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| Family |
MEGF family
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| Subcellular location |
Cell membrane
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| Function | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. May be involved in the early stages of hematopoiesis. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IPM Probe Info |
 |
C606(0.54) | LDD1701 | [1] | |
|
DBIA Probe Info |
 |
C725(1.11); C734(1.11) | LDD0078 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0020 | ARS-1620 | HCC44 | C725(1.11); C734(1.11) | LDD0078 | [2] |
| LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C606(0.54); C610(0.47) | LDD1702 | [1] |
| LDCM0022 | KB02 | CMK | C533(1.28) | LDD2302 | [3] |
| LDCM0023 | KB03 | MDA-MB-231 | C606(0.54) | LDD1701 | [1] |
| LDCM0024 | KB05 | MKN-1 | C610(1.03) | LDD3331 | [3] |
References