Details of the Target

General Information of Target

Target ID LDTP07240
Target Name Interleukin-23 receptor (IL23R)
Gene Name IL23R
Gene ID 149233
Synonyms
Interleukin-23 receptor; IL-23 receptor; IL-23R
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQ
PRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDIS
SGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYIN
ISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTII
YWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETG
KRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGM
IVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMN
NNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDL
NTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSL
SNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGI
VNEELPSINTYFPQNILESHFNRISLLEK
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 2 subfamily
Subcellular location
Cell membrane
Function
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
TTD ID
T00484
Uniprot ID
Q5VWK5
DrugMap ID
TT6H4QR
Ensemble ID
ENST00000347310.10
HGNC ID
HGNC:19100
ChEMBL ID
CHEMBL4296013

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.K404R .
HT115 SNV: p.S252P .
IGR37 SNV: p.L390F .
IGR39 SNV: p.L390F .
IGROV1 Deletion: p.K629SfsTer10 .
LS180 SNV: p.A364G .
LS513 SNV: p.V338A .
MCC13 SNV: p.P320S .
MEWO SNV: p.A223V; p.G547E .
MFE319 SNV: p.F594I .
NCIH2291 SNV: p.D349Y .
OVCAR4 SNV: p.Q413H .
RKO SNV: p.I552V .
SNU1 SNV: p.V134A .
SNU449 SNV: p.P580L .
TE10 SNV: p.T167A .
TE4 SNV: p.A55E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0177  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear nucleic acid-binding protein C1D (C1D) C1D family Q13901

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-il-23 Antibody D06ARV
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fm-303 Antibody D0Y0WW
Adc-1012 . D0G0AQ
Apg-2305 . D0YZ1J

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060