Details of the Target

General Information of Target

Target ID LDTP07199
Target Name RNA-binding E3 ubiquitin-protein ligase MEX3C (MEX3C)
Gene Name MEX3C
Gene ID 51320
Synonyms
RKHD2; RNF194; RNA-binding E3 ubiquitin-protein ligase MEX3C; EC 2.3.2.27; RING finger and KH domain-containing protein 2; RING finger protein 194; RING-type E3 ubiquitin transferase MEX3C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSGSSAALALAAAPAPLPQPPPPPPPPPPPLPPPSGGPELEGDGLLLRERLAALGLDDP
SPAEPGAPALRAPAAAAQGQARRAAELSPEERAPPGRPGAPEAAELELEEDEEEGEEAEL
DGDLLEEEELEEAEEEDRSSLLLLSPPAATASQTQQIPGGSLGSVLLPAARFDAREAAAA
AAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAALNGEQAALLRRKSVNTTECVPVPS
SEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHF
SMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYI
VTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGT
LGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWF
GDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPS
TPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPP
ESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
Uniprot ID
Q5U5Q3
Ensemble ID
ENST00000406189.4
HGNC ID
HGNC:28040

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C319(10.00)  LDD2157  [1]
DBIA
 Probe Info  		C319(1.53)  LDD1511  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C319(1.24)  LDD1520  [2]
 LDCM0289  AC29 HEK-293T C319(1.05)  LDD1528  [2]
 LDCM0298  AC37 HEK-293T C319(1.08)  LDD1537  [2]
 LDCM0307  AC45 HEK-293T C319(1.19)  LDD1546  [2]
 LDCM0312  AC5 HEK-293T C319(0.96)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C319(1.15)  LDD1555  [2]
 LDCM0325  AC61 HEK-293T C319(1.13)  LDD1564  [2]
 LDCM0248  AKOS034007472 HEK-293T C319(1.53)  LDD1511  [2]
 LDCM0367  CL1 HEK-293T C319(1.02)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C319(1.05)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C319(1.19)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C319(1.15)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C319(0.98)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C319(0.96)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C319(1.14)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C319(1.07)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C319(1.23)  LDD1604  [2]
 LDCM0409  CL21 HEK-293T C319(0.96)  LDD1613  [2]
 LDCM0413  CL25 HEK-293T C319(0.92)  LDD1617  [2]
 LDCM0422  CL33 HEK-293T C319(0.97)  LDD1626  [2]
 LDCM0426  CL37 HEK-293T C319(0.86)  LDD1630  [2]
 LDCM0435  CL45 HEK-293T C319(1.16)  LDD1639  [2]
 LDCM0439  CL49 HEK-293T C319(1.20)  LDD1643  [2]
 LDCM0448  CL57 HEK-293T C319(1.44)  LDD1651  [2]
 LDCM0453  CL61 HEK-293T C319(1.16)  LDD1656  [2]
 LDCM0461  CL69 HEK-293T C319(1.03)  LDD1664  [2]
 LDCM0466  CL73 HEK-293T C319(1.46)  LDD1669  [2]
 LDCM0475  CL81 HEK-293T C319(1.33)  LDD1678  [2]
 LDCM0479  CL85 HEK-293T C319(1.04)  LDD1682  [2]
 LDCM0484  CL9 HEK-293T C319(1.02)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C319(0.95)  LDD1691  [2]
 LDCM0492  CL97 HEK-293T C319(1.04)  LDD1695  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019