Details of the Target
General Information of Target
| Target ID | LDTP07146 | |||||
|---|---|---|---|---|---|---|
| Target Name | Synaptotagmin-6 (SYT6) | |||||
| Gene Name | SYT6 | |||||
| Gene ID | 148281 | |||||
| Synonyms |
Synaptotagmin-6; Synaptotagmin VI; SytVI |
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| 3D Structure | ||||||
| Sequence |
MSGVWGAGGPRCQEALAVLASLCRARPPPLGLDVETCRSFELQPPERSPSAAGAGTSVSL
LAVVVIVCGVALVAVFLFLFWKLCWMPWRNKEASSPSSANPPLEALQSPSFRGNMADKLK DPSTLGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTRLQRQTTEPASSTRHTSFKRHLP RQMHVSSVDYGNELPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYD YETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHF PVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESV DLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWN EMLAYPRKPIAHWHSLVEVKKSFKEGNPRL |
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| Target Bioclass |
Other
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| Family |
Synaptotagmin family
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| Subcellular location |
Membrane; Cytoplasm, cytosol; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
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| Function |
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C407(1.40) | LDD3423 | [1] | |
Competitor(s) Related to This Target