Details of the Target

General Information of Target

Target ID LDTP07143
Target Name KN motif and ankyrin repeat domain-containing protein 4 (KANK4)
Gene Name KANK4
Gene ID 163782
Synonyms
ANKRD38; KN motif and ankyrin repeat domain-containing protein 4; Ankyrin repeat domain-containing protein 38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRR
AKQAKFSTLPRNFSLPDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQAST
SRSEVSYHRKALLAEATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGL
SLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIPELVQEGAEPPEGVVK
VPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLL
EEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRT
EELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVH
GLLTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQLSLP
QGPEQVLTSSVHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWGSDRKTPPAGREETSS
NLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQ
SQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTK
KNLQFVGVNGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGI
PEGTCHAAQESGPGEEVPHSKAERYKPSEEFLNACRALSQHLPETGTTTDQLLRQSLNTI
SQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIV
KLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTAL
MLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTD
KAGRTALSIALKSPTHMEIAGLLRAHAEQGRSLGL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Uniprot ID
Q5T7N3
Ensemble ID
ENST00000354381.3
HGNC ID
HGNC:27263

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A827T .
AGS SNV: p.K462T .
GB1 SNV: p.E381K .
HCC15 SNV: p.G153V .
HCT15 SNV: p.L334F .
HT115 SNV: p.A80D; p.P87S .
ICC137 SNV: p.Y745H .
IM95 SNV: p.S630F .
KNS42 SNV: p.P311L .
MCC13 SNV: p.G734E .
NCIH2286 SNV: p.T975N .
NCIH23 SNV: p.P206H .
NCIH661 SNV: p.A134S .
OPM2 SNV: p.Q513H .
OVK18 SNV: p.S809Y .
SNU1 Insertion: p.L596SfsTer10 .
SNU308 SNV: p.F213L .
SW1783 SNV: p.A593T .
TE1 SNV: p.Q760H .
TF1 SNV: p.Q466R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C755(1.74)  LDD3472  [2]
W1
 Probe Info  		N.A.  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC18 C755(1.43)  LDD2385  [2]
 LDCM0023  KB03 ICC18 C755(1.84)  LDD2802  [2]
 LDCM0024  KB05 TFK-1 C755(1.74)  LDD3472  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-5 (CUL5) Cullin family Q93034
Histone acetyltransferase type B catalytic subunit (HAT1) HAT1 family O14929
Tyrosine-protein kinase CSK (CSK) Tyr protein kinase family P41240
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840