General Information of Target

Target ID LDTP07075
Target Name Pleckstrin homology domain-containing family S member 1 (PLEKHS1)
Gene Name PLEKHS1
Gene ID 79949
Synonyms
C10orf81; Pleckstrin homology domain-containing family S member 1; PH domain-containing family S member 1; Epididymis luminal protein 185; hEL185
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHH
HRGSIEIDQNSSVEVGISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDW
VSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKHL
MEQSSPGFRQTHLQDLSEATQDVKEENHYLTPRSVLLELDNIIASSDSGESIETDGPDQV
SGRIECHYEPMESSFFKETSHESVDSSKEEPQTLPETQDGDLHLQEQGSGIDWCLSPADV
EAQTTNDQKGNIPDESQVEKLNVFLSPPDVINYLALTEATGRICVSQWEGPPRLGCIFCH
GDHLLAVNDLKPQSLEEVSLFLTRSIQKEDSFRILSYQVAFGEGTELRDRAPGFRTSDRH
DVAKRACMESDWCRDSKTAPSTNLCLSFLFCKIMTNDGAGCWIIK
Target Bioclass
Other
Uniprot ID
Q5SXH7
Ensemble ID
ENST00000361048.6
HGNC ID
HGNC:26285

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C22(1.81)  LDD2267  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX142 C22(1.81)  LDD2267  [1]
 LDCM0023  KB03 BRX211 C358(2.26)  LDD2685  [1]
 LDCM0024  KB05 BRX142 C22(2.22)  LDD3101  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840