Details of the Target

General Information of Target

Target ID LDTP06973
Target Name von Willebrand factor A domain-containing protein 2 (VWA2)
Gene Name VWA2
Gene ID 340706
Synonyms
AMACO; von Willebrand factor A domain-containing protein 2; A domain-containing protein similar to matrilin and collagen; AMACO; Colon cancer secreted protein 2; CCSP-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSN
SVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKR
MVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTV
FAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSSAICSSATPDCRVEAH
PCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFLTHPATCYRTTCPGPCD
SQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLLFLLDSSAGTTLDGFL
RAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPT
LTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVGS
EAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSA
SVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQ
APYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGI
SVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQDVLIEWLCGEAKQPVNLCKPSP
CMNEGSCVLQNGSYRCKCRDGWEGPHCENRFLRRP
Target Bioclass
Other
Subcellular location
Secreted
Uniprot ID
Q5GFL6
Ensemble ID
ENST00000392982.8
HGNC ID
HGNC:24709

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P298T; p.G353V DBIA    Probe Info 
COLO678 SNV: p.S424I DBIA    Probe Info 
EFO27 SNV: p.Q504P .
HCT15 SNV: p.G741D DBIA    Probe Info 
HT115 SNV: p.D165N .
LNCaP clone FGC SNV: p.N657K .
MCC13 SNV: p.P275L .
NCIH2172 SNV: p.R526W .
NCIH358 SNV: p.R643G .
SKMEL24 SNV: p.D699N .
SKMEL5 SNV: p.G160R .
SKNSH SNV: p.G327Ter .
SW1271 SNV: p.R416L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C290(0.98)  LDD3310  [1]
BTD
 Probe Info  		C340(0.74)  LDD2113  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0520  AKOS000195272 MDA-MB-231 C340(0.74)  LDD2113  [2]
 LDCM0022  KB02 AGS C242(2.20)  LDD2263  [1]
 LDCM0023  KB03 AGS C242(2.11)  LDD2680  [1]
 LDCM0024  KB05 COLO792 C290(0.98)  LDD3310  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C340(1.04)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) Protein-tyrosine phosphatase family P26045
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060