Details of the Target

General Information of Target

Target ID LDTP06963
Target Name PDZ domain-containing protein 11 (PDZD11)
Gene Name PDZD11
Gene ID 51248
Synonyms
AIPP1; PDZK11; PISP; PDZ domain-containing protein 11; ATPase-interacting PDZ protein; Plasma membrane calcium ATPase-interacting single-PDZ protein; PMCA-interacting single-PDZ protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGF
NIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI
SMRVRFFPYNYHRQKERTVH
Target Bioclass
Other
Subcellular location
Secreted; Cytoplasm
Function Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.
Uniprot ID
Q5EBL8
Ensemble ID
ENST00000239666.9
HGNC ID
HGNC:28034

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.R133H .
IGROV1 SNV: p.R46Ter .
MCAS SNV: p.D101G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K115(10.00)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270