Details of the Target

General Information of Target

Target ID LDTP06961
Target Name Mesoderm-specific transcript homolog protein (MEST)
Gene Name MEST
Gene ID 4232
Synonyms
PEG1; Mesoderm-specific transcript homolog protein; EC 3.-.-.-; Paternally-expressed gene 1 protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQ
DSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSI
FEQASIVEALLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGI
FPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIR
NNDGNLVIDSLLQYINQRKKFRRRWVGALASVTIPIHFIYGPLDPVNPYPEFLELYRKTL
PRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF
Target Bioclass
Enzyme
Family
AB hydrolase superfamily
Subcellular location
Endoplasmic reticulum membrane
Uniprot ID
Q5EB52
Ensemble ID
ENST00000223215.10
HGNC ID
HGNC:7028
ChEMBL ID
CHEMBL4523324

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.S125N .
HDMYZ SNV: p.L105V .
SKMEL5 SNV: p.E90K .
SW1990 Deletion: p.S228VfsTer23 .
TOV21G SNV: p.K192N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C174(1.40)  LDD3409  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AN3-CA C174(1.47)  LDD2264  [1]
 LDCM0023  KB03 AN3-CA C174(2.07)  LDD2681  [1]
 LDCM0024  KB05 RL95-2 C174(1.40)  LDD3409  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840