Details of the Target
General Information of Target
| Target ID | LDTP06951 | |||||
|---|---|---|---|---|---|---|
| Target Name | Caveolae-associated protein 4 (CAVIN4) | |||||
| Gene Name | CAVIN4 | |||||
| Gene ID | 347273 | |||||
| Synonyms |
MURC; Caveolae-associated protein 4; Muscle-related coiled-coil protein; Muscle-restricted coiled-coil protein |
|||||
| 3D Structure | ||||||
| Sequence |
MEHNGSASNADKIHQNRLSSVTEDEDQDAALTIVTVLDKVASIVDSVQASQKRIEERHRE
MENAIKSVQIDLLKLSQSHSNTGHIINKLFEKTRKVSAHIKDVKARVEKQQIHVKKVEVK QEEIMKKNKFRVVIFQEKFRCPTSLSVVKDRNLTENQEEDDDDIFDPPVDLSSDEEYYVE ESRSARLRKSGKEHIDNIKKAFSKENMQKTRQNLDKKVNRIRTRIVTPERRERLRQSGER LRQSGERLRQSGERFKKSISNAAPSKEAFKMRSLRKGKDRTVAEGEECAREMGVDIIARS ESLGPISELYSDELSEPEHEAARPVYPPHEGREIPTPEPLKVTFKSQVKVEDDESLLLDL KHSS |
|||||
| Target Bioclass |
Other
|
|||||
| Family |
CAVIN family
|
|||||
| Subcellular location |
Cytoplasm, myofibril, sarcomere
|
|||||
| Function |
Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes. Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C141(5.01); C288(2.09) | LDD3401 | [1] | |
Competitor(s) Related to This Target