Details of the Target

General Information of Target

Target ID LDTP06942
Target Name RUN domain-containing protein 3A (RUNDC3A)
Gene Name RUNDC3A
Gene ID 10900
Synonyms
RAP2IP; RPIP8; RUN domain-containing protein 3A; Rap2-interacting protein 8; RPIP-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN
FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST
ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI
DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL
VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN
QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK
LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSC
KSLASFKSNECLVSDSPEGSPALSPS
Target Bioclass
Other
Family
RUNDC3 family
Function May act as an effector of RAP2A in neuronal cells.
Uniprot ID
Q59EK9
Ensemble ID
ENST00000225441.11
HGNC ID
HGNC:16984

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 Insertion: p.D435RfsTer65
SNV: p.V198A;p.D435H		 .
HEC1 SNV: p.V109M .
HEC1B SNV: p.V109M .
NCIH1793 SNV: p.W94Ter .
PF382 SNV: p.R91W .
SNGM SNV: p.R150W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C108(1.27)  LDD3344  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 NCI-H146 C108(1.46)  LDD2510  [1]
 LDCM0023  KB03 NCI-H146 C108(1.41)  LDD2927  [1]
 LDCM0024  KB05 NCI-H146 C108(1.27)  LDD3344  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840