Details of the Target

General Information of Target

Target ID LDTP06912
Target Name Coiled-coil domain-containing protein 92 (CCDC92)
Gene Name CCDC92
Gene ID 80212
Synonyms
Coiled-coil domain-containing protein 92; Limkain beta-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCT
DLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLE
NTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASP
SGSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAM
PDPTPFLLARESAEVHLIKERPLVIPPIASDRSGEQHSPAREKPHKAHVGVAHRIHHATP
PQAQPEVKTLAVDQVNGGKVVRKHSGTDRTV
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function
Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface.
Uniprot ID
Q53HC0
Ensemble ID
ENST00000238156.8
HGNC ID
HGNC:29563

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C88(1.46)  LDD3367  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C59(0.99)  LDD1508  [3]
 LDCM0277  AC18 HEK-293T C59(0.90)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C59(1.04)  LDD1518  [3]
 LDCM0286  AC26 HEK-293T C59(1.03)  LDD1525  [3]
 LDCM0295  AC34 HEK-293T C59(0.91)  LDD1534  [3]
 LDCM0304  AC42 HEK-293T C59(0.97)  LDD1543  [3]
 LDCM0313  AC50 HEK-293T C59(0.93)  LDD1552  [3]
 LDCM0321  AC58 HEK-293T C59(0.99)  LDD1560  [3]
 LDCM0405  CL18 HEK-293T C59(0.98)  LDD1609  [3]
 LDCM0419  CL30 HEK-293T C59(0.92)  LDD1623  [3]
 LDCM0432  CL42 HEK-293T C59(1.00)  LDD1636  [3]
 LDCM0445  CL54 HEK-293T C59(0.93)  LDD1648  [3]
 LDCM0451  CL6 HEK-293T C59(0.88)  LDD1654  [3]
 LDCM0458  CL66 HEK-293T C59(0.93)  LDD1661  [3]
 LDCM0471  CL78 HEK-293T C59(0.92)  LDD1674  [3]
 LDCM0485  CL90 HEK-293T C59(0.87)  LDD1688  [3]
 LDCM0022  KB02 769-P C88(1.27)  LDD2246  [2]
 LDCM0023  KB03 769-P C88(1.52)  LDD2663  [2]
 LDCM0024  KB05 NUGC-3 C88(1.46)  LDD3367  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Centrosomal protein of 164 kDa (CEP164) . Q9UPV0
Coiled-coil domain-containing protein 92 (CCDC92) . Q53HC0
Four and a half LIM domains protein 2 (FHL2) . Q14192

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402